Jeffrey Mital

Jeffrey Mital

Assistant Professor of Biomedical Sciences

BS, SUNY College Geneseo; PhD, University of Vermont


Biomedical Sciences
Echlin Center  224

(203) 582-6545
Jeffrey.Mital@quinnipiac.edu
EC-BMS

BMS 278   Research and Technology   -   Spring 2015
BMS 522   Immunology   -   Fall 2014
BMS 569   Antimicrobial Therapy   -   Spring 2015
HSC 375   Clinical Immunology   -   Fall 2014

Curriculum Vitae

Courses Taught

Undergraduate

  • Research and Technology (BMS278)
  • Microbiology Laboratory (BMS370L)
  • Immunology Laboratory (BMS375L)

Graduate
  • Immunology (BMS522)
  • Antimicrobial Therapy (BMS569)
  • Virology (BMS570)

All Publications

Peer Reviewed Publications

1. Mital, J., Miller, N., Dorward, D., Dooley, C., and T. Hackstadt. (2013) “A Role for Chlamydial Inclusion Membrane Proteins in Inclusion Membrane Structure and Biogenesis.” PLoS One 17;8(5).

2. Parussini, F., Tang, Q., Moin, S., Mital, J., Urban, S., and G. Ward (2012) “Intramembrane proteolysis of Toxoplasma Apical Membrane Antigen 1 facilitates host cell invasion but is dispensable for replication.” PNAS 109(19):7463-8.

3. Mital, J. and T. Hackstadt (2011) “A role for Src-family kinases in sphingolipid acquisition by chlamydiae.” Infect and Immun 79(11):4559-68.

4. Mital, J. and T. Hackstadt (2011) “Diverse requirements for Src-family tyrosine kinases distinguish chlamydial species.” mBio 2(2). (editor’s pick, selected for commentary, and recommended by Faculty of 1000)

5. Mital, J., Miller, NJ., Fischer, ER., and T. Hackstadt (2010) “Specific chlamydial inclusion membrane proteins associate with active Src family kinases in microdomains that interact with the host microtubule network.” Cell Micro 12 (9): 1235-49. (highlighted on cover)

6. Mital, J., and G. Ward (2007) “Current and emerging approaches to studying invasion in Apicomplexan parasites.” Molecular Mechanisms of Parasite Invasion. Ed. Barbara Burleigh and Dominique Soldati. Landes Biosciences.

7. Brydges, S., Zhou, X., Huynh, M., Harper, J., Mital, J., Adjogble, K., Daubener, W., Ward, G., and V. Carruthers (2006) “Targeted deletion of MIC5 enhances trimming proteolysis of Toxoplasma invasion proteins.” Euk Cell 5(12): 2174-83. (cover)

8. Mital, J., Schwarz, J., Taatjes, D., and G. Ward (2006) “Laser scanning cytometer-based assays for measuring host cell attachment and invasion by the human pathogen Toxoplasma gondii.” Cytometry 69(1): 13-19.

9. Mital, J., Meissner, M., Soldati, D., and G. Ward (2005) “Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA-1) demonstrates that TgAMA-1 plays a critical role in host cell invasion.” Mol Biol Cell 16(9): 4341-9. (featured article in ASCB In-cytes newsletter)

10. Alexander, D., Mital, J., Ward, G., Bradley, P., and J. Boothroyd (2005) “Identification of the moving junction complex of Toxoplasma gondii: A collaboration between distinct secretory organelles.” PLoS Pathog 1(2): 137-49. (recommended by Faculty of 1000)

11. Carpi, A., and J. Mital (2000) “The expanding use of forensics in environmental science.” Environmental Science and Technology 34(11): 262-6.

Updated Pubmed Listing

Educational Background

Undergraduate:
BS in Biochemistry, SUNY Geneseo, magna cum laude

Graduate:
Ph.D in Microbiology and Molecular Genetics, University of Vermont

Post Doctoral:
National Institutes of Health, Rocky Mountain Laboratories, Laboratory of Intracellular Parasites

Research Interests

Cellular Microbiology
My lab studies how the obligate intracellular bacterial pathogen Chlamydia interacts with and takes over mammalian host cells. The role of host kinases during Chlamydia trachomatis and Chlamydia caviae pathogenesis and development is currently being investigated.

Techniques:

  • Molecular Cloning
  • Recombinant DNA techniques
  • Mammalian Cell Culture
  • Mammalian Cell Transfection
Immunobiology
There are clinical benefits to laser treatment for multiple sclerosis and other autoimmune disorders. To elucidate the cellular mechanisms underlying these clinical benefits, T cell signaling responses to laser treatment are being investigated.

Techniques
  • ELISA
  • Mammalian Cell Culture
  • SDS-PAGE and Western Blotting