Martine M Mirrione

Martine M Mirrione

Assistant Professor of Biomedical Sciences

BS, Marist College; PhD, SUNY at Stony Brook


Biomedical Sciences
Echlin Center  236

(203) 582-8117
Martine.Mirrione@quinnipiac.edu
EC-BMS

BMS 203   Introductory Medical Terminology   -   Spring 2015
BMS 320   Pharmacology   -   Spring 2015
HSC 225   Writing in the Health Professions   -   Spring 2015

Educational Background

BS in Biology, Marist College, Poughkeepsie, NY

PhD in Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, NY

All Publications

Peer-reviewed – Research Publications

1.
*Li B, *Piriz J, *Mirrione M, *Chung C, Proulx C, Schulz D, Henn F, Malinow R. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature. 2011 Feb 24:470(7335):535-9. *authors contributed equally PMID: 21350486

2.
Emmetsberger J, Mirrione MM, Zhou C, Fernandez Monreal M, Tsirka SE. Tissue Plasminogen Activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4. Journal of Neuroscience. 2010 May 12;30(19):6538-47. PMID: 20463217

3.
Mirrione MM, Konomos D, Gravanis I, Dewey SL, Heppner FL, Aguzzi A, Tsirka SE. Microglial ablation and lippoplysaccharide preconditioning affects pilocarpine-induced seizures in mice. Neurobiology of Disease. 2010 Jul;39(1):85-97. Epub 2010 Apr 9. PMID: 20382223

4.
Schulz D, Mirrione MM, Henn FA. Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl. Neurobiology of Learning and Memory. 2010 Feb;93(2):291-301. Epub 2009 Nov 29. PMID: 19931627

5.
Mirrione MM, Schiffer WK, Fowler JS, Alexoff DL, Dewey SL, Tsirka SE. A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator. Neuroimage. 2007 Oct 15;38(1):34-42. PMID: 17707126

6.
Schiffer WK, Mirrione MM, Dewey SL. Optimizing experimental protocols for behavioral neuroimaging in rodents. Journal of Nuclear Medicine. 2007 Feb;48(2):277-87. PMID: 17268026

7.
Schiffer WK, Mirrione MM, Biegon A, Alexoff DL, Patel V, and Dewey SL. Serial microPET measures of the metabolic reaction to a microdialysis probe implant. Journal of Neuroscience Methods. 2006 Sep 15;155(2):272-8. PMID: 16519945

8.
Mirrione MM, Schiffer WK, Siddiq M, Dewey SL, and Tsirka SE. PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy. Synapse. 2006 Feb;59(2):119-21. PMID: 16320304


Peer-Reviewed – Book Chapters and Reviews

1.
Mirrione MM, Tsirka SE. Neuroimaging in animal seizure models with 18FDG PET. Epilepsy Research and Treatment, Dr. H.E. Scharfman (Ed.), Volume 2011 (2011), Article ID 369295, 8 pages doi:10.1155/2011/369295

2.
Mirrione MM, Tsirka SE. A Functional Role for Microglia in Epilepsy, Clinical and Genetic Aspects of Epilepsy, Dr. Zaid Afawi (Ed.), ISBN: 978-953-307-700-0, InTech, 2011. Available from: http://www.intechopen.com/articles/show/title/a-functional-role-for-microglia-in-epilepsy

3.
McGinty VB, Hayden BY, Heilbronner SR, Dumont EC, Graves SM, Mirrione MM, du Hoffmann J, Sartor GC, España RA, Millan EZ, Difeliceantonio AG, Marchant NJ, Napier TC, Root DH, Borgland SL, Treadway MT, Floresco SB, McGinty JF, Haber S. Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference. Behavioral Brain Research. 2011 Nov 20;225(1):348-57. Epub 2011 Jul 26. PMID: 21816177

Research Interests

  • Neuroscience
  • Pharmacology
  • Neuroimaging
  • Behavior


I am interested in exploring the neuronal circuits underlying depressive-like behavior and examining the mechanisms related to the therapeutic efficacy of deep brain stimulation for treating depression.

Postdoctoral Experience

Neuroscience Department at Cold Spring Harbor Laboratory (2010-2013)

Medical Neuroimaging Department at Brookhaven National Laboratory (2007-2010)

Teaching & Research Philosophy

In the classroom and laboratory setting, my goal is to engage student interest by creating a lively interactive atmosphere for maximizing the learning potential of each individual student.

My approach includes using visuals to help students learn important principles and concepts, connecting ideas with hands-on experiments, and challenging students with in class questions and activities.

Throughout my basic science education and training, I have also realized that I very much enjoy mentoring students on research projects particularly in my favorite areas, pharmacology and neuroscience.

I am delighted to help students realize the joy of scientific exploration, practice critical thinking, promote well controlled and well powered experiments, and develop communication skills through disseminating scientific data.